|
KMID : 0043320100330101685
|
|
Archives of Pharmacal Research
2010 Volume.33 No. 10 p.1685 ~ p.1690
|
|
|
The effects of daidzin and its aglycon, daidzein, on the scopolamineinduced memory impairment in male mice
|
|
Kim Dong-Hyun
Jung Hyun-Ah
Park Se-Jin
Kim Jong-Min
Lee Seung-Joo
Choi Jae-Sue
Cheong Jae-Hoon
Ko Kwang-Ho
Ryu Jong-Hoon
|
|
|
Abstract
|
|
|
|
In this study, the effect of daidzin or daidzein isolated from Pueraria lobata on the memory impairments induced by scopolamine was assessed in male mice using the passive avoidance and the Morris water maze tasks. Administration of daidzin (5 mg/kg) or daidzein (5 mg/kg) significantly reversed the scopolamine (1 mg/kg)-induced cognitive impairments in male mice as evidenced by the passive avoidance test (p < 0.05) and on the Morris water maze test (p < 0.05). Moreover, the ameliorating effects of daidzin or daidzein were antagonized by tamoxifen (1 mg/kg), the nonspecific estrogen receptor antagonist. These results indicate that daidzin or daidzein may be useful in cognitive impairment induced by cholinergic dysfunction, and this beneficial effect is mediated, in part, via estrogen receptor.
|
|
|
KEYWORD
|
|
|
Daidzin, Daidzein, Learning and memory, Estrogen receptor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|